Genetic links to pouch failure
نویسندگان
چکیده
منابع مشابه
Gi-biased β2AR signaling links GRK2 upregulation to heart failure.
RATIONALE Phosphorylation of β(2)-adrenergic receptor (β(2)AR) by a family of serine/threonine kinases known as G protein-coupled receptor kinase (GRK) and protein kinase A (PKA) is a critical determinant of cardiac function. Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-established causal factor of heart failure, but the underlying mechanism is poorly understood. OBJEC...
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ژورنال
عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology
سال: 2009
ISSN: 1759-5045,1759-5053
DOI: 10.1038/nrgastro.2009.54